Verletzung umbilical Blutfluß

vascular implants

Verletzung umbilical Blutfluß Treat trophischen Geschwüren Essen Thrombophlebitis Verletzung umbilical Blutfluß


Verletzung umbilical Blutfluß

Die Erfindung betrifft eine Vorrichtung zur Simulation gynäkologischer Verletzung umbilical Blutfluß. The invention relates to a device for simulating gynecological operations. Um eine Vorrichtung zum Simulieren gynäkologischer Operationen zu schaffen, die eine möglichst realistische Simulation ermöglicht, wird im Vorrichtung zur Simulation gynäkologischer Operationen Verletzung umbilical Blutfluß for simulation of gynecological operations translated from German DE A1.

In order to provide a device for simulating gynecological operations, which enables realistic simulation, is proposed in the invention that an artificial female pelvis with pelvic openings for the urethra, the vagina and the rectum and the pelvic floor muscles is provided with obturator foramen and ischial are closed and in the pool, an artificial rectum, an artificial urinary bladder, an artificial urethra, artificial ureter, an artificial small intestine, artificial vessels, artificial ligaments, an artificial vagina and an artificial nerve plexus, said the pelvis while leaving spaces for Operations Verletzung umbilical Blutfluß is lined with a layer of artificial adipose tissue and is provided on an artificial peritoneum.

Es Verletzung umbilical Blutfluß somit ein künstliches weibliches Becken vor, an dem Operationstechniken realitätsgetreu geübt oder getestet werden können.

There is therefore an artificial female pelvis, Verletzung umbilical Blutfluß, can be practiced or tested on the surgical techniques realistically. Device for simulation of gynecological operations, characterized in that an artificial female pelvis with pelvic openings for the urethra, the vagina and the rectum and the pelvic floor muscles is provided with obturator foramen and are ischial sealed and in the pool, an artificial rectum, an artificial urinary bladder, an artificial urethra, artificial ureter, an artificial small intestine, artificial vessels, artificial ligaments, Verletzung umbilical Blutfluß, artificial vagina and an artificial nerve plexus are arranged, wherein the basin is lined with release of spaces for Operations inlays with a layer of artificial adipose tissue and an artificial peritoneum is provided.

Apparatus according to claim 1, characterized in that gynecological Operations inlays are inserted in the spaces of the basin. Apparatus according to claim 2, characterized in that the inlays are attached by means of operating locking pins, needles or nails.

Device according to one of claims 1 to 3, characterized in that the artificial female pelvis can be introduced in a simulation doll. A device according to claim 4, characterized in that the legs of the manikin are configured movable. Iliaca com, Iliaca ext. Device according to one of claims 1 to 5, characterized in that the iliac vessels com, iliac ext. Device according to one of claims 1 to 6, characterized in that the bands Lig.

Device according to one of claims 1 to 7, characterized in that the urethra is formed so that it moves slowly in contact and means for detecting a track-wise are provided overheating of the ureter. Device according to one of claims 1 to 8, characterized in that coagulable structures, in particular coagulable vessels are formed from umbilical cords, in particular of umbilical cords of animals. Device according to one of claims 1 to 9, characterized in that by means of adhesive coagulable meat muscle is formed.

Device according to one of claims 1 to 10, characterized in that body-like structures from the combination of Verletzung umbilical Blutfluß materials with cloth-like materials are formed. Die The DE 20 U1 DE 20 U1 beschreibt ein anatomisches Trainingsmodell für chirurgische Behandlungsverfahren bestehend aus einer ersten, Verletzung umbilical Blutfluß, Hartgewebe simulierenden Schicht und einer zweiten darauf angebrachte, Weichgewebe simulierenden Schicht, wobei zwischen der ersten und der wenigstens einen zweiten Schicht eine auf der ersten Schicht fest haftende und zur zweiten Schicht definiert lösbar haftende Grenzschicht vorgesehen ist.

Aus der From the DE 20 U1 DE 20 U1 ist ein Simulator zur Simulation chirurgischer Eingriffe, insbesondere in der Herz- und Thoraxchirurgie, bekannt, welcher ein Gestell mit einer ersten Wand und einer zweiten Wand aufweist, wobei in der ersten Wand eine Durchtrittsöffnung angeordnet ist, wobei an der zweiten Wand wenigstens eine variable Wand in wenigstens zwei verschiedenen Positionen anordenbar ist und wobei die variable Chaga mit Krampfadern wenigstens eine Öffnung aufweist und wobei vorzugsweise wenigstens ein künstliches Körperteil zum Einsetzen in die Öffnung der variablen Wand vorgesehen ist.

Das Trainieren von Operationstechniken an menschlichen Leichen ist insofern problematisch, als bei diesen keine physiologischen Prozesse mehr ablaufen, wie z. The training of surgical techniques to human bodies is problematic insofar as these expire no physiological processes more such, Verletzung umbilical Blutfluß. As a perfusion of the tissue and also a hazard of the surgeon, for example, due to infection HIV, hepatitis, etc.

An fixierten Leichen z. At fixed bodies z. In addition, the fixer changes the organ consistency, so that for Verletzung umbilical Blutfluß, the feel is no longer comparable to the intraoperative situation. Es besteht daher ein Bedarf für Vorrichtungen zum Simulieren gynäkologischer Operationen zu schaffen, Verletzung umbilical Blutfluß, um Ärzten zu ermöglichen, bereits etablierte Diagnose- und Operationstechniken zu erlernen und auch neue Diagnose- und Operationstechniken zu testen, Verletzung umbilical Blutfluß.

There is therefore a need for devices for simulating gynecological operations to create, in order to allow physicians to learn already established diagnostic and surgical techniques and test new diagnostic and surgical techniques.

Die Aufgabe der vorliegenden Erfindung besteht darin, eine Vorrichtung zum Simulieren gynäkologischer Operationen zu schaffen, die eine möglichst realistische Simulation ermöglicht. The object of the present invention is to provide an apparatus for simulating gynecologic operations that allows a realistic simulation.

This object is inventively achieved in that an artificial female pelvis with pelvic openings for the urethra, the vagina and the rectum and the pelvic floor muscles is provided with obturator foramen and are ischial sealed Verletzung umbilical Blutfluß in the pool, an artificial rectum, an artificial bladder, artificial urethra, artificial ureter, an artificial small intestine, artificial vessels, artificial ligaments, artificial vagina and an artificial nerve plexus are arranged, wherein the basin is lined with release of spaces for Operations inlays with a layer of artificial adipose tissue and an artificial peritoneum is provided.

Anhand einer solchen Vorrichtung lassen sich senkungskorrigierende Verfahren, wie z. Sakropexie, Pectopexie, lateral repair, Inkontinenzoperationen, wie z. On the basis of such a device can reduce corrective Verletzung umbilical Blutfluß such.

As the Endo-Burch and gynecological operations on the organs of the pelvis uterus, ovaries, vagina, bladder ureter and urethra, colon and rectum, including the corresponding displacement rooms with peritoneum, fatty tissue, Obturationsloge, Paracervicalem tissue, Retzius space, space rectovaginal, Lymphknotenloge, etc. Als ausgewählte Beispiele Verletzung umbilical Blutfluß die künstliche Sakropexie und die Pectopexie, welche Verfahren zur Korrektur des vaginalen Deszensus sind und die künstliche supracervicale Hysterektomie LASHwelches ein Routineeingriff in gynäkologischen Abteilungen ist, vorgestellt.

As selected examples are artificial sacropexy and Pectopexie which method to correct vaginal prolapse are and artificial supracervicale hysterectomy LASHwhich is a routine procedure in gynecological departments presented. Das Becken kann hierfür mit speziellen gynäkologischen Operations-Inlays, beispielsweise für Verletzung umbilical Blutfluß, Organentfernungen oder -teilentfernungen, organerhaltende oder wiederherstellende Operationen und Inkontinenzoperationen, versehen werden.

The basin can be therefor, provided with special gynecological Operations inlays, for example, for reduction surgery, organ distances or -teilentfernungen, organ-preserving or reconstructive surgery and incontinence surgery.

Die Operations-Inlays werden jeweils spezifisch für eine bestimmte Operationsart hergestellt und nach erfolgter Operation aus dem Beckenmodell entfernt.

The Operations inlays are each made specifically for a particular type of operation and removed after surgery from the basin model. It is within the invention that the Operations inlays can be inserted and fastened in the spaces provided for this Verletzung umbilical Blutfluß in the basin. It is advantageous that the operation can be secured by means of inlays locking pins, needles or nails.

A preferred embodiment of the invention is that the artificial female pelvis can be introduced into a simulation doll. Hierdurch wird die Operation noch realitätsgetreuer, da mittels der Simulationspuppe die Körperkontur und die Haut simuliert werden können.

As a result, trophischen Geschwüren bei Hunden Foto operation is still real-life, since by means of the simulation doll body contour and skin can be simulated. In this context, it is particularly advantageous that the legs of the manikin are configured movable.

Dies ermöglicht es, die Simulationspuppe so auf einem Operationstisch anzuordnen, wie dies bei einer Patientin der Fall wäre. This allows the simulation doll so placed on an operating table, Verletzung umbilical Blutfluß would be the case in a patient. Ferner ist die Abspreizbarkeit der Beine notwendige Voraussetzung für die digitale vaginale Kontrolle bestimmter gynäkologischer Operationen z.

Furthermore, the Abspreizbarkeit the legs is a necessary condition for the Verletzung umbilical Blutfluß vaginal control of certain gynecological surgeries z. Burch surgery or lateral repair, TLH. In the invention, it is provided that the vessels iliac com, iliac ext. Depending on the operation inlay can also include additional or other vascular variations for the simulation of pathologies, in particular one or more of the uterine artery, ovarian artery, T.

It is inventively that the bands Lig. Auch hier können gegebenenfalls zusätzliche oder andere Bänder, insbesondere eines oder mehrere von Lig. Again, if necessary, additional or different bands, in particular one or more of Lig. A preferred embodiment of the invention is that human adipose tissue in the body is modeled using spherical structures in combination with a gel-like substance.

It has been found in the invention that by means of spherical structures as having Sago, combined with a gel-like substance such as silicone human adipose tissue can be very well imitated in terms of its consistency. It is within the invention that is the ureters formed Verletzung umbilical Blutfluß that it moves slowly to the touch and means for detecting a track-wise overheating of the ureter are provided.

Furthermore, it is advantageous that coagulable structures, in particular coagulable vessels are formed from umbilical cords, Verletzung umbilical Blutfluß, in particular of umbilical cords of animals. It is expedient that means meat glue coagulable muscles is formed, Verletzung umbilical Blutfluß. Also within the scope of the invention that the body-like structures from the combination of silicone-type materials are formed with textile-like materials. The combination of silicone-type materials silicone, acrylic and textile-like materials eg.

A preferred embodiment of the invention is that artificial nerves are arranged with an electrical conductor in the basin. Dies ermöglicht die Detektion einer Verletzung eines der Nerven.

This allows the detection of a violation of one of the nerves. Finally, it is advantageous that the blood flow through the vessels can be simulated by means of a pump. It may for simplicity be simulated Verletzung umbilical Blutfluß flow through the vessels in a different direction than the anatomically correct, because it in operations only on the visibility of the pulsations or a filling of the tank with interchangeable, Verletzung umbilical Blutfluß, potentially vulnerable structures takes to make the surgeon related stress has as under real conditions.

If an additional complete venous system is introduced, also an anatomically correct blood flow can be modeled. Verletzung umbilical Blutfluß wird die Erfindung anhand zweier Ausführungsbeispiele näher erläutert.

The invention using two exemplary embodiments will be explained in more detail. Für die Sakropexie- und Pectopexiemodelle gibt es vorzugsweise einen wiederverwendbaren Teil a sowie einen Teil, der für jede Operation neu hergestellt wird Teil b. For Sakropexie- and Pectopexiemodelle there is preferably a reusable part a and a part that is re-established for each operation part b.

Die Herstellung beider Teile wird nachfolgend erläutert: The production of both parts will be explained below: Made of plastic a bony female pelvis with the respective basin openings is first produced, which fits exactly into the shape corresponding simulation doll Real Simulator.

Example, by the company B 3 Scientific, Verletzung umbilical Blutfluß, may be used. Die Beckenbodenmuskeln sowie der M. Piriformis werden anhand von Schablonen aus 5 Krampfadern Behandlung von tiefen dickem Filz hergestellt.

The pelvic floor muscles and the piriformis muscle are made using templates made of 5 mm thick felt. Die Muskulatur wird mit transparentem Silikon Baumarkt silikonisiert. The muscles are siliconized with transparent silicone hardware store. Das Centrum tendineum und sehnige Übergangsbereiche werden mit dreifach gefalteten Kompressen, die mit Silikon imprägniert werden, nachempfunden, Verletzung umbilical Blutfluß. The central tendon and sinewy transition areas with triple folded compresses, which are impregnated with silicone, modeled.

Die einzelnen Teile werden mit Zwirn aneinandergenäht und mit Schrauben im Becken verankert. The individual parts are sewn together with twine and anchored with screws in the pelvis. Three holes for the urethra, the vagina and the rectum remain on the typical places, Verletzung umbilical Blutfluß.

In das so hergestellte Becken werden folgende nachgebildete Strukturen eingebracht: In the thus prepared basin following simulated structures are introduced: Rectum, Blase, Urethra, Ureteren, A. Rectum, bladder, urethra, ureters, iliac artery com, iliac ext. Iliopectineum, Scheide mit oder ohne Cervixstumpf, Nervenplexus und Peritoneum. Iliopectineum, vagina with or without Cervixstumpf, nerve plexus and peritoneum. Es ist selbstverständlich möglich, nur diejenigen dieser Strukturen in das Becken einzubringen, Verletzung umbilical Blutfluß für die jeweilige Operation von Relevanz sind.

It is of course possible to incorporate only those of these structures in the basin, which are relevant for the respective operation. Die Strukturen werden z. The structures are prepared, for example, as follows.:


Error (Not Found)!!1 Verletzung umbilical Blutfluß

Verwendung von vegf zur herstellung eines medikaments zur behandlung oder verhinderung der intimalen hyperplasie und verabreichungsgerät Use of VEGF for the manufacture of a medicament for the treatment or prevention of intimal hyperplasia and administration device translated from German DE T2.

Use according to claim 1, wherein the blood vessel is an artery. Verwendung nach Anspruch 1 oder 2, zur Behandlung oder Prävention einer Stenose, die durch einen operativen Eingriff hervorgerufen wurde oder mit einer Pulmonal-Arteriellen Hypertension verbunden ist. Use according to claim 1 or 2, for the treatment or prevention of stenosis induced by a surgical procedure or associated with a pulmonary arterial hypertension.

Verwendung nach Anspruch 3, in welcher es sich beim operativen Eingriff um Angioplastie, koronare Bypass-Operation, Verletzung umbilical Blutfluß, operative Anastomose oder Endarteriektomie handelt. Use according to claim 3, in which it is the surgery to angioplasty, coronary bypass surgery, surgical anastomosis or endarterectomy.

Use according to one of the preceding claims for treating or preventing stenosis of blood vessels. Use according to one of the preceding claims for the treatment or prevention of restenosis of blood vessels. Verwendung nach einem der vorstehenden Ansprüche, in welcher der Wirkstoff eine Nukleinsäure in Verbindung mit einem viralen oder nicht-viralen Vektor ist. Use according to Verletzung umbilical Blutfluß of the preceding claims, in which the active substance is a nucleic acid in association with a viral or non-viral vector.

An implant for therapeutic use, which is so designed that it, on or close to the point which is placed to be treated or preventing intimal hyperplasia in which the endothelium is wholly or largely intact, and containing an active substance according to any one of the preceding claims. Ein Implantat nach Anspruch 9, das ein Silastik-Implantat oder ein biologisch abbaubares Implantat ist, Verletzung umbilical Blutfluß.

An implant according to claim 9, which is a silastic implant or a biodegradable implant. An implant according to claim 9 or 10 in the form of a sleeve which is adapted to be treated or prevented by hyperplasia in a blood vessel at or Verletzung umbilical Blutfluß the site.

An implant according to any one Verletzung umbilical Blutfluß claims 9 to 11, whose outer wall is impermeable to the active substance contained in it substantially.

Use according to any one of claims 1 to 8, for use in the feeding of the active substance into a blood vessel in a patient, wherein the active ingredient is provided in a carrier which is adapted to ensure a seal around the vessel, wherein the active ingredient in the device is held or connected thereto, Verletzung umbilical Blutfluß, so that it comes in use into contact with the adventitial surface. Die vorliegende Erfindung betrifft die therapeutische Verwendung eines vaskulären endothelialen Wachstumsfaktors, insbesondere zur Behandlung und Prävention der Intimahyperplasie von Blutgefässen und anderer Zustände, insbesondere Bluthochdruck.

The present invention relates to the therapeutic use of a vascular endothelial growth factor, particularly for the treatment and prevention of intimal hyperplasia of blood vessels and other conditions, especially hypertension.

Die Erfindung betrifft auch eine Vorrichtung, die Preis operatsії auf Krampfadern die Verabreichung des aktiven Wirkstoffes verwendet werden kann. The invention also relates to a device which can be used for administration of the active agent. Hintergrund Verletzung umbilical Blutfluß Erfindung Background of the Invention. Intimahyperplasie ist die Zunahme der Zellzahl zwischen dem Endothel und der Lamina elastica interna eines Blutgefässes, Verletzung umbilical Blutfluß, insbesondere in der dortigen Endothelschicht Intima oder in einer Arterie.

Intimal hyperplasia is the increase in cell number between the endothelium and internal Creme Wachs Varizen lamina of a blood vessel, in particular in the local endothelial lining intima or in an artery.

Intimal hyperplasia is often caused by smooth muscle cell Verletzung umbilical Blutfluß in the blood vessel wall. When intimal hyperplasia occurs, this can lead to a de novo Verletzung umbilical Blutfluß of the endothelial or vascular wall, Verletzung umbilical Blutfluß, ie stenosis. This allows the blood vessels are closed. Also, if a restriction has been eliminated in a blood vessel, perform a postoperative intimal hyperplasia occurring to the fact that the artery closes again, Verletzung umbilical Blutfluß.

Dies ist als Restenose bekannt. This is known as restenosis. A proliferation of arterial smooth muscle cells commonly occurs when a blood vessel, for. Example an artery, is deformed or destroyed during a surgical procedure. Zum Beispiel kann eine Intimahyperplasie zur De-novo-Stenose infolge von Bypassgrafts führen, in welchen eine Vene mit einer Arterie verbunden wird, und allgemein infolge chirurgischer Verletzung umbilical Blutfluß. For example, intimal hyperplasia to de novo stenosis as a result of bypass grafts result in which a vein with an artery is connected, and generally as a result of surgical anastomosis.

Zwei Beispiele von chirurgischen Eingriffen, die zu Stenose führen können, sind koronare Bypassgrafts und femoro-popliteale arterielle Oberschenkel-Bypassgrafts. Two examples of surgical procedures that can lead to stenosis, coronary artery bypass grafts and are femoro-popliteal arterial femoral bypass grafts.

Ähnlich kann Restenose infolge von Ballonangioplastie-Verfahren auftreten, die dazu verwendet werden, Verengungen in Blutgefässen zu beseitigen, beispielsweise Ballonangioplastie-Verfahren. Similarly, restenosis may occur as a result of balloon angioplasty procedures used to eliminate constrictions in blood vessels, such as balloon angioplasty procedures, Verletzung umbilical Blutfluß.

Intimahyperplasie, ob sie zu Stenose oder zu Restenose führt, bleibt ein Hauptproblem nach unterschiedlichen chirurgischen Verfahren. Intimal hyperplasia, whether it leads to stenosis or restenosis, remains a major problem after various surgical procedures. Atherosclerotic cardiovascular disease is the leading cause of death in Europe and North America and cause a highly significant morbidity Verletzung umbilical Blutfluß to occlusion of the arterial lumen, blood flow either preventing or inhibiting, a plaque with superimposed thrombosis with possible distal embolization, weakening of the arterial wall leading to the aneurysmal expansion and possibly to Rupture lead.

Abhängig von Lokalisation und Krankheitsverlauf existieren mehrere Behandlungsmöglichkeiten, mit dem arteriellen Bypassgraft als den geläufigsten chirurgischen Eingriff. Depending on the location and course of the disease, there are several treatment options, with the arterial bypass graft as the most common surgical procedure.

In the aorta, Verletzung umbilical Blutfluß, renal vessels, mesenteric and peripheral vessels increases the burden of surgical bypass procedures with surgery rates in the United States and Europe by perinhabitants continuing.

Zusammen beträgt die Zahl der jährlich vorgenommenen chirurgischen Bypassverfahren annähernd eine Million. Together, the number of surgical bypass procedures undertaken annually is approximately one million. In the first 24 months after surgery suggests a very significant number of arterial bypass grafts fail Seal. This means that for all made annually in the UK cardiac and peripheral arterial bypass procedures may be expected approximately Die Fehlschlagrate bei Wiederholungsverfahren liegen sogar noch höher.

The failure rate for repeat procedures are even higher. There are three main reasons why grafts fail within five years after surgery. Späteres Fehlschlagen, nach 24 Monaten, ist hauptsächlich das Ergebnis eines Fortschreitens des ursprünglichen Arterioskleroseprozesses.

Later failure, after Verletzung umbilical Blutfluß months, is mainly the result of progression of atherosclerosis original process. In these cases, it is SMC intimal hyperplasia one that is responsible for progressive narrowing, z, Verletzung umbilical Blutfluß.

Typically, the SMC intimal hyperplasia at the distal arterial anastomosis and the native vessel wall is located opposite the anastomosis. Es handelt sich somit um eine primäre Pathologie an dieser Stelle und nicht um eine Restenose an der Stelle einer vorhergehenden Intimahyperplasie, wie es infolge Angioplastie der Fall sein Verletzung umbilical Blutfluß. It is thus a primary pathology at this site and not restenosis at a site of previous intimal hyperplasia as might be the case as a result of angioplasty.

SMC-Intimahyperplasie kann an der proximaleren arteriellen Anastomose und entlang dem Graft selbst auftreten. SMC intimal hyperplasia can occur even in the more proximal arterial anastomosis and along the graft. Stenose und Restenose stellen weiterhin beide bedeutende Probleme nach chirurgische Eingriffen dar.

Stenosis and restenosis continues to provide both significant problems is by surgical intervention. Heutzutage sind zahlreiche Methoden zur Behandlung und Prävention der Intimahyperplasie getestet worden, aber keine war klinisch zufriedenstellend, Verletzung umbilical Blutfluß. Today, numerous methods have been tested for the treatment and prevention of intimal hyperplasia, but none were clinically satisfactory.

Vascular endothelial growth factor VEGF is a naturally occurring protein, Verletzung umbilical Blutfluß. Beim Menschen kommen mindestens vier Formen mit, Verletzung umbilical Blutfluß, und Aminosäuren vor. In humans at least four forms occur with, and amino acids. Eine genomische Teilsequenz ist auch gegeben. A partial genomic sequence is also given. It should be understood that this numbering refers to the number of each amino acid of the mature protein.

The translated protein also includes a presequence of 26 amino acids that is naturally cleaved during intracellular processing. VEGF is known to play Verletzung umbilical Blutfluß role in angiogenesis, where the division of vascular Verletzung umbilical Blutfluß cells EC stimulates increased endothelial permeability and acts as an endothelial "survival factor" in retinal vessels. Beispielsweise kann VEGF in rekombinanter Form oder wenn von einem Vektor exprimiert die Entwicklung neuer Blutgefässe induzieren, wenn es intraarteriell in ischämische Extremitäten injiziert wird.

For example, VEGF can induce, when injected intra-arterially into ischemic limbs in recombinant form or when expressed from a vector, the development of new blood vessels.

Diese Eigenschaft hat zu seiner Verwendung bei der Reparatur von Arterien geführt, deren Endothele während chirurgischer Eingriffe verletzt wurden. This property has led to its use in repairing arteries whose endothelia have been damaged during surgery. So haben Asahara et al.

It was found that VEGF stimulated the re-endothelialization of the artery which, Verletzung umbilical Blutfluß, in turn, appeared to contribute to suppression of intimal hyperplasia. VEGF protein and gene are disclosed in WO-A, and their use for the treatment of Krampfadern auf der Ebene Sie können fliegen to the vascular epithelium, diabetic ulcers and injuries of blood vessels have been proposed.

VEGF fragments are described in WO-A, and their use in angiogenesis and re-endothelialization of inner vascular walls, such. As in the treatment of ulcers. GB-A discloses a non-restrictive porous outer stent for arteriovenous bypass graft procedures, Verletzung umbilical Blutfluß. This stent has beneficial effects on lumen size and media and intimal thickening. WO-A discloses a device for local administration of a substance in a blood vessel, comprising a reservoir formed between two of its elements.

Their use requires implantation, ie cutting through the vessel and then securing the device to the vessel walls. Die Vorrichtung ist teilweise porös. The device is partially porous. The reservoir is in direct contact with the blood flow in the lumen. Dies birgt das Risiko einer Infektion. This carries the risk of infection.

US-A discloses a device for administering a drug to the adventitia of a blood vessel. Sie ist mit permanenten Wänden und transkutanen Sonden ausgestattet für die Verabreichung von Medikamenten in flüssiger Form. It is provided Varizen Regeln Bandagierung permanent walls and transcutaneous probes for the administration of medicaments in Verletzung umbilical Blutfluß form.

The aim is that the drug should go to a different place. Zusammenfassung der Erfindung Summary of the Invention. Surprisingly, properties of VEGF have been identified, suggesting that it can be used in various ways against intimal hyperplasia, Verletzung umbilical Blutfluß.

A cuff was placed around the outside a rabbit artery. This procedure usually causes intimal hyperplasia in the rabbit artery, leading to thickening of the arterial wall, which is comparable to the stenosis that can occur in human arteries following bypass operations. Eine Intimahyperplasie wurde unterdrückt. Intimal hyperplasia was suppressed. It has been shown that the Adventitiamanschette is suitable for arterial gene transfer with all tested gene delivery systems.


Part 1 - Babbitt Audiobook by Sinclair Lewis (Chs 01-05)

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